### Multcomp-1.98 README file

                                 INTRODUCTION

    multc97 is a menu-driven program which provides all necessary
    computations for implementing the design strategy for monitoring
    multiple outcomes in clinical trials described in the following
    three papers.

    Thall, Peter F., Simon, R. and Estey, E.H. "Bayesian sequential
    monitoring designs for single-arm clinical trials with multiple
    outcomes," Statistics in Medicine 14:357-379, 1995.

    Thall, Peter F., Simon, R. and Estey, E.H. "New statistical strategy
    for monitoring safety and efficacy in single-arm clinical trials," J.
    Clinical Oncology 14:296-303, 1996.

    Thall, Peter F. and Sung, Hsi-Guang, "Some Extensions and Applications
    of a Bayesian Strategy for Monitoring Multiple Outcomes in Clinical
    Trials,"
     (submitted for publication).

                              HOW IT WAS WRITTEN

    multc97 was written in ANSI C, compiled by GNU C compiler gcc. All the
    examples in the paper (*) were run on a DEC Alpha machine.

                           LEGALITIES (BRIEF)

        We want to make  this  program as widely   available  as possible.
    Hence, executable code derived  from  the source provided, the  source
    itself, and the accompanying  documentation  may be freely  copied and
    distributed  provided  that  this   copyright section accompanies such
    copies.  We encourage the distribution of this code on bulletin boards
    and as shareware.

        Modifications and improvements to the code can similarly be freely
    copied and distributed.  Peter F. Thall and Hsi-Guang Sung  would
    appreciate  a copy of  any such improvements for incorporation into
    later versions of multc97.

        Source code  may be extracted    and used for  any  non-commercial
    purpose.  Non-commercial means that  at most a modest distribution fee
    is charged, as shareware.  We would  appreciate acknowledgment of such
    use of our code.

        Commercial use of the source code requires written permission from
    the Department of Biomathematics at the above  address.  Our policy is
    generally to grant  such  permission  provided appropriate   credit is
    given to us in the documentation.

                                 INSTALLATION

    For step-by-step instructions, please see the file 'INSTALL'. Sample
    sessions and tutorials can be found in file 'Examples'.

                     OBTAINING SOURCE AND OTHER VERSIONS

    The C source code is available via anonymous ftp from
    odin.mdacc.tmc.edu (129.106.1.6) in the subdirectory /pub/source.
    The current version is for UNIX.
    MS-DOS PC and  MacIntosh executables will be available in the near future.

                             CONTACTING THE AUTHORS

    To contact the authors of multc97 or report any bugs, please write to:

              Peter F. Thall
              Department of Biomathematics, Box 237
              University of Texas M. D. Anderson Cancer Center
              1515 Holcombe Boulevard
              Houston, TX 77030

    or send electronic mail to:

    rex@odin.mdacc.tmc.edu